Coordinador
La División de Ingeniería Biomédica es un claro ejemplo del enfoque multidisciplinar del I3A, aúna especialistas en Biología, Medicina, Físicas, Matemáticas e Ingeniería que cooperan para desarrollar soluciones tecnológicas que mejoren la salud y la calidad de vida.
Las tecnologías actuales de diagnóstico, monitorización, terapia, cirugía y asistencia a las personas con discapacidad engloban casi todos los campos de la Ingeniería.
Líneas generales de investigación
- Ingeniería de tejidos y biomateriales
- Modelado biológico y biomecánica
- Tratamiento de señales y imágen médica. Instrumentación médica
- Tecnologías preventivas y asistenciales
Palabras clave
Mecanobiología, biomateriales, ingeniería de tejidos, microfluídica, biorreactores, dispositivos de diagnóstico, modelado del comportamiento celular, comportamiento microestructural de biomateriales, electrofisiología cardiaca, telemedicina, codificación automática de señales biomédicas, protocolos de transmisión de información biomédica, sensores inteligentes, algoritmos de visión por computador para detección humana, rastro y reconocimiento de actividad, diseño de prótesis, células madre mesenquimales, terapias de enfermedades neurodegenerativas, genómica y genética de priones, interfaces hombre-máquina adaptados, localización y guía en entornos interiores y exteriores.
Proyectos
Terapias RNAi cardioselectivas traslacionales y corazón-en-chip predictivos para abordar los desafíos clínicos cardíacos
Llegar a un dispositivo lo más miniaturizado posible, que permita pedir ayuda a través de un botón y que pueda ser llevado siempre por la persona mayor
In silico framework to improve the personalized prediction of progression and outcomes in thoracic and abdominal aortic aneurysms based on personalized clinical and mechanical biomarkers
To develop a computational-experimental framework to improve the prediction of the initiation, progression and final outcome of the pathology.
Optimización y automatización del proceso de congelación de tejido ovárico para preservar la fertilidad en niñas que padecen cáncer
Financiar principalmente acciones muy concretas que mejoren la calidad de vida de los niños con cáncer y sus familias.
Computational biomechanics and bioengineering 3d printing to develop a personalised regenerative biological ventricular assist device to provide lasting functional support to damaged hearts
BRAV3 desarrollará un dispositivo biológico duradero capaz de bombear junto con un corazón dañado mediante el diseño de un tejido regenerador a partir de biomateriales, células madre y el modelado informático avanzado con diseños imprimibles en 3D
To validate technically and clinically novel methods to understand, and give support to tremor diagnosis.
By developing biological ventricular assist devices (BioVADs), BRAV3 will bring a quantum leap in regenerative medicine and its translation towards the clinic, as well as impact the development of novel medical technologies whilst greatly advancing our knowledge on human heart development.
Computational modeling of cell culture in dynamically adaptive multilayer microenvironment charged with drug-delivery microcapsules
Develop computational tools for the predictive analysis of key factors in the evolution of multiple myeloma and cartilage, and spinal cell growth and more...
Diseño integrado con inteligencia artificial e ingeniería de multi-organoides bioimpresos en chInvestigador principal para diagnóstico y terapia tumoral
Digital transformation of clinical practice by using patient-specific cardiac digital twins for risk prediction and therapy optimization
Construction of patient-specific digital twins of the human heart by statistical and mechanistic in silico modeling, fed with extensive clinical data collected and processed digitally
El objetivo fundamental es el desarrollo de una metodología integral para la corrección y el tratamiento de asimetrías mandibulares en niños.
Customised DNA-based nanocarriers to boost heart healing
DNABEATS aims to bring advanced materials to regenerate injured myocardium.
Extracting the Human Motor Null Space from Muscles - A new framework to measure human neural activity
ECHOES will capitalize on recent breakthroughs in decoding the spinal outputs to muscles to develop a theoretical and experimental framework to unveil the 'motor null space' in human muscles.
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Predict and prevent foot pathologies related to hallux limitus and flat feet
Predict and prevent foot pathologies related to hallux limitus and flat feet
In vitro characterization and in vitro/in vivo simulation of the effect of hypoxia and drug dosis in glioblastoma growth
Se propone el estudio in vitro e in silico del tumor de glioblastoma multiforme (GBM).
Individual and Collective Migration of Immune Cellular Systems
El objetivo de ICoMICS es desarrollar una novedosa plataforma de simulación virtual para investigar cómo las células inmunitarias terapéuticas (TIC) detectan, se mueven e interactúan con las células cancerosas y con el microambiente tumoral.
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multI-discipliNary, multi-Sectoral and multi-national trainIng network on Digital biomarkErs for supraventricular arrHythmia charactErizAtion and Risk assessmenT
Establishing a multi-disciplinary network to tackle the design and the early-phase validation of digital biomarkers, specifically targeting the diagnosis of supraventricular arrhythmias (SVAs) and their associated potential for adverse risk assessment, via the joint combination of signal processing, artificial intelligence and non-clinical devices.
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In silico models for tendinomuscular injuries analysis using artificial intelligence techniques
To continue characterizing the in vitro mechanical properties of tissues present in the ankle joint of a mouse model and extend the study to those involved in the shoulder's rotator cuff. In the case of muscles, the active behavior will also be analyzed by inducing contraction through an external electrical signal.
Methods for Stroke Monitoring and Diagnosing based on BCG
To develop novel, non-invasive methods for detecting cardiac and non-cardiac disease in stroke patients using the ballistocardiogram (BCG) signal, allowing for patient monitoring without transfer to clinical settings
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COMPUTER-AIDED EFFECTIVE FRACTURE RISK STRATIFICATION OF PATIENTS WITH VERTEBRAL METASTASES FOR PERSONALISED TREATMENT THROUGH ROBUST COMPUTATIONAL MODELS VALIDATED IN CLINICAL SETTINGS
METASTRA will propose new guidelines for the stratification and management of metastatic patients. METASTRA approach is expected to cut the uncertain diagnoses from the current 60% down to 20% of cases. This will reduce patient suffering, and allow cutting expenditure by 2.4B€/year.
To improve diagnosis and monitoring of sleep apnea-hypopnea syndrome (SAHS)
Deepening knowledge and improving the Quality of Life in Parkinson Disease through Smart Insoles
To develop intelligent insoles that will allow, by means of force and inertial sensors and advanced algorithms, to monitor the patient's gait and provide personalised information on the patient's evolution.
Optimización de tratamientos personalizados para fracturas femorales mediante gemelos digitales y aprendizaje automático
PELVIc Floor Evaluation live TRACKing – Real-time prediction of perineal trauma
To develop the first-ever solution to predict pelvic floor tearing
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Arquitecturas de control microelectrónicas para convertidores electrónicos de potencia inteligentes basados en semiconductores de gap ancho
Gemelo digital para la detección, el diagnóstico asistidos del cáncer de próstata y la simulación de los efectos y la eficacia de diferentes tratamientos oncológicos
Desarrollar una herramienta computacional para crear un gemelo digital 4D: un modelo virtual diseñado para reflejar con precisión toda la próstata de un paciente y de su posible tumor
Implementation and validation of a closed-loop neural interface to entrain brain rhythms and reduce motor symptoms in Parkinson's Disease
To develop a non-invasive neuromodulation platform to apply closed-loop stimulation protocols synchronized with brain oscillations decoded from the periphery with muscle recordings
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ECG morphology clusters for sudden cardiac death risk stratification in coronary artery disease using genetics and human-based computational models
Integrate the information from the genetic architecture of the distinct ECG morphological clusters to understand the mechanisms underlying SCD risk.
Unlocking data content of Organ-On-Chips
To develop groundbreaking Organ-on-Chips (OOC) technologies to mitigate the challenges posed by use of animals in drug development and testing. Direct use of human cells is a real game changer, bridging the gender gap and allowing personalized medicine.
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VAScularised Tumour Organoids on a chip with human placenta vessels as a preclinical model for anticancer therapies
VASTO Proof of Concept aims to develop and test an innovative microfluidic-based platform, which allows to evaluate the efficacy of different cell immunotherapy strategies against solid tumours.
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