Biomedical Engineering

Research groups

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Many rare diseases cause chronic health problems or are even life-threatening. The impact on the quality of life of affected patients, of whom many are children, is significant. To date, a limited but increasing number of so-called orphan drugs (drugs for rare diseases) are reaching patients.

However, the majority of rare diseases are still without any effective treatment. The development of novel human systems for drug discovery therefore represents a major public health priority. Microfluidic technology-based “Organs-on-a-chip” represents a powerful tool for investigating rare disease mechanisms and testing new drug and treatment due to their ability to mimic tailored micro-environment architecture inspired by organ-level functions in vivo.


Argira is a system that generates information of great relevance for the generation of knowledge in the changes of different aquatic environments (seas, lakes, estuaries, etc.), in particular to measure temperature, pressure

In silico three-dimensional modeling of the interaction between tumor cells and mesenchymal stem cells in a BioMicrogel Extracellular Matrix

Cell culture is a complex process that involves stimuli, cell-cell and cell-matrix interaction. The minimal variation of these parameters, which are correlated with each other, can alter the lineage and cell viability.

Computational biomechanics and bioengineering 3D printing to develop a personalized regenerative biological ventricular assist device to provide lasting functional support to damaged hearts

3D printing to restore a damaged heart
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The objective of this Project is to model the psychophysiological response of subjects exposed to hyperbaric environments, identifying the physiological parameters that better characterize this response. This will allow, in the near future, an early identification of dysfunctional psychophysiological states that can be risky for the health of the subjects.

"Heart On chip" based on induced pluripotent stem cell technology for personalized medicine

"Organs-on-a-chip" based on microfluidic technology represents a powerful tool for investigating rare disease mechanisms and testing new drugs and treatments due to its ability to mimic bespoke microenvironment architecture inspired by organ-level functions in vivo.
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By developing biological ventricular assist devices (BioVADs), BRAV3 will bring a quantum leap in regenerative medicine and its translation towards the clinic, as well as impact the development of novel medical technologies whilst greatly advancing our knowledge on human heart development.

Configuración y optimización autónomas de redes de seguridad pública basadas en LTE

The objective of the project is the design of efficient mechanisms for (re) configuration, and / or autonomous optimization or with minimal supervision of network deployments in the event of failure, congestion and changes in service needs and network capacity of the operators .

The objective is the development of a digital twin of a banknote reading machine.

Advanced methodologies for performance evaluation and QoX in telematic networks and services

El objetivo de la Red Temática en Sistemas Avanzados de Evaluación de Prestaciones y QoX (Resource), es planificar futuras actividades conjuntas y asentar resultados de actividades de I+D+I obtenidos anteriormente por los miembros de la red.

In vitro characterization and in vitro/in vivo simulation of the effect of hypoxia and drug dosis in glioblastoma growth

The in vitro and in silico study of glioblastoma multiforme (GBM) tumor is proposed.

Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface

Knowing the aging rhythms of the heart and developing patterns that help prevent arrhythmias are some of the objectives of the Modelage project, led by Esther Pueyo, a researcher at the BSICoS group.
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Accelerating Innovation in Microfabricated Medical Devices

The overall goal of Moore4Medical is to accelerate innovation in electronic medical devices.
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MultidisciplinarY training network for ATrial fibRillation monItoring, treAtment and progression

The main scope of MY-ATRIA is to establish a multidisciplinary network able to develop research and training “without walls” among academic, industrial and clinical entities in the area of cardiac, atrial disease
European Commission

The project is expected to make major scientific contributions to depression monitoring, to the characterization and interpretation of ANS from the joint analysis of physiological signals, and to daily-life ANS monitoring.

In this project, several of the main technological challenges in relation to these arrhythmias are addressed

PRedictive In-silico Multiscale Analytics to support cancer personalized diaGnosis and prognosis, Empowered by imaging biomarkers

PRIMAGE will address the study of two types of pediatric cancer that have a high mortality and therapeutic complexity: neuroblastoma and diffuse glioma of the brainstem.

Advanced and versatile PRInting platform for the next generation of active Microfluidic dEvices

PRIME will reduce the gap between microfluidics and non-specialized laboratories and end users, allowing the diffusion and penetration of the technology in various fields of application, as well as its geographical expansion to areas where large equipment is difficult to transport or resources they are scarce
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Remote Assessment of Disease and Relapse in Central Nervous System Disorders

The project aims to develop new ways of monitoring major depressive disorder, epilepsy, and multiple sclerosis using wearable devices and smartphone technology.

The RADAR-CNS project aims to develop new ways of monitoring major depressive disorder, epilepsy, and multiple sclerosis using wearable devices and smartphone technology. The key goal of the project is to improve patients’ symptoms and quality of life and also to change how these and other chronic disorders are treated.

Biomechanical evaluation of Lapidus plates and decision support system in flatfoot surgery in adults

Agencia Estatal de Investigación

This project aims at providing a comprehensive characterization of cardiac changes induced by the mentioned highly prevalent CVDs as well as by physiological aging and non-cardiac diseases/conditions associated with increased cardiovascular risk.

The main objective of this project is the design and manufacture of microfluidic platforms for cultivating tumor organoids in 3D.