The next Avicenna Alliance Members Webinar is planned for 4 April 2023 at 5pm CET
Title: "In silico models of coronary artery pathophysiology for clinical decision support" by Prof. Frans van de Vosse from Eindhoven University of Technology
This initiative is available to all Avicenna Alliance and VPHi members ONLY.
Abstract
Obstructed coronary artery disease is one of the main causes of myocardial ischemia and can be treated by medication or by clinical interventions such as PCI (percutaneous coronary intervention) or CABG (coronary artery bypass grafting). In cases where the right decision how to intervene is not clear from X-ray or CT imaging of the obstruction, invasive (measured) fractional flow reserve (FFR), using a sensor equipped guidewire, is the “gold standard” for assessing the physiological significance of coronary artery disease during invasive coronary angiography. The FFR then is defined as the ratio between the time averaged pressure distal and proximal to the obstruction. Despite the fact that FFR-guided percutaneous coronary intervention improves patient outcomes and reduces stent insertion and cost, due to several practical and operator related factors, it is used in less than 10% of percutaneous coronary intervention procedures. Virtual fractional flow reserve (vFFR) using an in-silico model of the coronary artery blood flow in pathophysiological conditions has emerged as an attractive alternative to invasive FFR. In this webinar an overview of the development of the in-silico models and use for clinical decision making will be given. In addition, the possible use for future in-silico clinical trials to optimize procedures and medical devices will be discussed in the context of the generated synthetic data collections using hybrid (mechanistic-data driven) models.
Short Bio
Frans van de Vosse leads the research group Cardiovascular Biomechanics at the department of Biomedical Engineering. His research interests are related to the computational and experimental biomechanical analysis of the cardiovascular system and its application to clinical diagnosis and intervention, cardiovascular prostheses, extracorporeal systems and medical devices. Research at the Cardiovascular Biomechanics group is directed along the topics Blood in Motion, Heart at Work, and Vessels under Stress. The common denominators are the development of computational models, experimental techniques and medical devices, for clinical diagnosis, decision support, and intervention.
You can register and find further information at this link