El viernes 20 de mayo tendrá lugar la conferencia Induced pluripotent stem cells In disease modelling and experimental therapies: cardiovascular perspective, impartida por Józef Dulak (Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland).
Organizada por el grupo Tissue Microenvironment Lab, la charla se enmarca en el marco del proyecto europeo CISTEM y se celebrará a las 12h en el Seminario del I3A (ed. I+D, bloque 5, 2ª planta).
Puede seguirse también online a través de la plataforma ZOOM:
https://zoom.us/j/91030954601
Código de acceso: 420886
Abstract. Induced pluripotent stem cells (iPSC) are generated by genetic reprogramming of somatic cells and thanks to the ability to differentiate into almost all cells types of the organism they offer the enormous possibilities for investigating disease mechanisms, drug sensitivity and safety and for experimental regenerative approaches. iPSC thus became the indispensable tools of current medial biotechnology and received additional input thanks to the development of the CRISPR/Cas9 gene editing.
In this lecture I will review our research in which we apply iPSC and CRISPR/Cas9 gene editing for investigating the iPSC-differentiation to cardiomyocytes, endothelial cells and other cell types linked with the disease affecting vascular system, heart and the skeletal muscles. The special attention will be on discussing the potential of iPSC for diabetes and Duchenne muscular dystrophy disease modelling. Application of iPSC-derived cardiomyocytes offer the chance for effective cell therapy of heart failure and this will be addressed in regard to our recently published studies.